PDRN is traditionally associated with salmon-derived sources, however L'Oréal Paris’ PDRN+ is produced through biotechnology via bio-fermentation and is vegan*. It is smaller in both molecular weight and size compared to traditional salmon-derived PDRN, and is 3000x smaller than a pore for optimal absorption into the skin’s surface.
Traditional PDRN is often extracted and purified from the sperm DNA of salmon trout or chum salmon — a process that has been standard in aesthetic medicine for decades.
L'Oréal Paris’ exclusive** PDRN+ is produced entirely through bio-fermentation — a biotechnological process that creates PDRN without any animal-derived ingredients. The result is a complex of PDRN and PRN (polyribonucleotide) that is pure and vegan*.
L'Oréal Paris' bio-fermented PDRN+ is 3,000x smaller than a pore size, which ensures optimal absorption into the skin’s surface when applied topically. It is also smaller in both molecular weight and size vs traditional salmon-derived PDRN.
In the L’Oréal Paris Revitalift Filler Hyaluronic PDRN+ Anti-Wrinkle Plumping Serum, vegan* PDRN+ is paired with a multi-weight Hyaluronic Acid complex for a formula that hydrates skin and leaves it glowing, plump and smooth. While PDRN+ is known to help boost radiance and improve skin quality, HA is known to deliver immediate surface-level results: Macro HA hydrates and smooths, Micro HA replumps and reduces the look of fine lines, and Micro-Epidermic HA — 50x smaller — penetrates deeper into the skin’s surface for sustained plumping.
The serum itself reflects the same values as its ingredients: a fluid, transparent, lightweight gel texture that delivers an addictive sensory experience — it applies effortlessly onto the skin, absorbs fast, and leaves no sticky or greasy residue. Inspired by K-Beauty and powered by L'Oréal Paris science, it is inspired by the skin booster procedures that have transformed aesthetic medicine — now in a vegan, at-home topical format.
"PDRN marks the transition from protection to bio-stimulation. Acting as a true 'skin Red Bull,' it restores glow and elasticity. Paired with HA, it forms the ultimate 'Power Couple': HA provides immediate comfort at the surface, PDRN ensures long-lasting transformation." — Dr. Marie-Céline Frantz*, Small Molecule Bioactives & Nucleic Acids Expert, L'Oréal R&I #GlowBoost
"Korea is the epicentre of beauty including aesthetics procedures and there I witnessed the steep rise of skin boosters (yes I did it too). So, when I started working on the Filler-procedure inspired Filler franchise pioneering Hyaluronic Acid, it was only natural that I explored the skin booster key active PDRN. Now our No.1 Anti-ageing serum is powered by Hyaluronic Acid and biotechnological PDRN (not salmon!) to help enhance your skin quality, glow and elasticity!" — Chang Yeunhee, Global Skincare Marketing Director, L'Oréal Paris
The World’s #1 Anti-Ageing Serum delivers an instant and visible skin transformation on glow, hydration, and overall skin quality:
| Glow & hydration | Result |
| Instant dewy skin | 69% of women agree |
| Radiant skin | 80% of women agree |
| Long-lasting glow | 80% of women agree |
| Plumpness improved | In just 1 hour |
| The look of Fine lines reduced | -60% |
| The look of Wrinkles reduced | -47% |
Tested for all skin types and tones, including sensitive skin.
Clinical scoring, 53 women, 6 weeks.
*Ingredient of animal origin **Exclusive to the L'Oréal Groupe until 2028
*Important Note: Claims from Dr. Frantz are based exclusively on published scientific literature:
Is the PDRN+ in this serum vegan*?
What makes this PDRN+ suitable for topical use?
How do I use it?
Will I see a difference in my glow?
