Benefits of using PDRN for Smoother, Plumper-Looking Skin

Smooth, plump skin isn't just about genetics — it's a reflection of what's happening beneath the surface. When collagen, elastin, and hyaluronic acid production slow down with age, the skin's structure weakens, volume fades, and texture becomes uneven. PDRN — a breakthrough ingredient inspired by aesthetic medicine — offers a new way to address these concerns by working directly at the cellular level.

In the L'Oréal Paris Revitalift Filler Hyaluronic PDRN+ Anti-Wrinkle Plumping Serum, L'Oréal Paris combines PDRN+ with Hyaluronic Acid for a visible skin transformation — after use, skin is left looking glowing, plump and smoother.

Why Does Skin Lose Its Smoothness and Plumpness?

Skin plumpness comes from the dermis — the deeper layer where collagen provides structure, elastin gives bounce, and hyaluronic acid retains water to keep everything full and cushioned. With age, fibroblasts — the cells that produce these compounds — gradually lose their activity. Research has shown that this decline is particularly pronounced in papillary dermal fibroblasts, which play a key role in maintaining the skin's surface architecture.

As these structural components diminish, the skin's surface starts to reflect the changes underneath. Fine lines form where collagen is thinnest. Texture becomes rougher as cell renewal slows. Volume loss creates hollowing, especially around the cheeks and under the eyes. External factors like UV exposure, pollution, and glycation compound the problem by actively breaking down existing collagen and elastin — accelerating the transition from plump, smooth skin to thin, uneven skin.

What does PDRN do for my skin?

PDRN (polydeoxyribonucleotide) is a DNA-derived ingredient traditionally sourced from salmon sperm. It has become a highly sought-after ingredient in k-beauty and aesthetic clinics, where it is renowned for its ability to help improve overall skin quality and radiance.

L'Oréal Paris' exclusive PDRN+ is a complex of PDRN and PRN produced through bio-fermentation — pure, vegan*, and 3,000x smaller than a pore size for optimal absorption into the skin’s surface. Inspired by K-Beauty skin booster procedures**, it is exclusive to L'Oréal Group.

*Ingredient not of animal origin
**Revitalift Filler Hyaluronic PDRN+ Serum is a cosmetic skincare product for topical use. Results not equal to a procedure.

The Dual Ingredients: PDRN + Hyaluronic Acid

While PDRN is known to work deep within the skin’s surface to help rebuild volume, Hyaluronic Acid is known for helping address smoother and plumper looking skin.

The L'Oréal Paris Revitalift Filler Hyaluronic PDRN+ Serum has been formulated to leave skin glowing, plump and smooth. The serum's fluid lightweight texture delivers an addictive sensory experience — fast-absorbing, non-sticky, and non-greasy.

"PDRN marks the transition from protection to bio-stimulation. Acting as a true 'skin Red Bull,' it restores glow and elasticity. Paired with HA, it forms the ultimate 'Power Couple': HA provides immediate comfort at the surface, PDRN ensures long-lasting transformation." — Dr. Marie-Céline Frantz*, Small Molecule Bioactives & Nucleic Acids Expert, L'Oréal R&I #GlowBoost

"Over time, our cells produce less HA, less collagen and elastin. PDRN steps in to wake up this metabolism using biocompatible nucleotides the body naturally recognizes. Its action is unique because it creates a true cellular dialogue to boost epidermis vitality and restore skin radiance. In this cross-talk with Hyaluronic Acid, PDRN goes even further: it resets the capacity of the skin to produce its own HA. The arrival of this technology in topical skincare is a major breakthrough." — Dr. Saliou Ngom*, Natural Ingredients Development Expert, L'Oréal R&I #WakeUpYourSkin

Proven Smoothing and Plumping Results

The #1 Anti-Ageing Serum in the World has been clinically tested to deliver a visible skin transformation in plumpness, smoothness, and wrinkle reduction. Here's a closer look at the results:

Average results – ¹Clinical study with 58 women after 8 weeks, twice daily use. ²Clinical study with 53 women after 6 weeks, twice daily use. Expert visual grading. Individual results will vary.

Tested for all skin types and tones, including sensitive skin.

*Important Note: Claims from Dr. Frantz are based exclusively on published scientific literature:

• Squadrito et al., "Pharmacological Activity and Clinical Use of PDRN," Frontiers in Pharmacology, 2017
• Kim et al., "Polynucleotide and Hyaluronic Acid Mixture for Skin Wound Healing," Tissue Eng Regen Med, 2025
• Akaberi et al., "PDRN in Skincare and Cosmetics: Mechanisms and Applications," J Skin Stem Cell, 2025

Sources:

• Meunier et al., "UVA Exposure Combined with Glycation of the Dermis Are Two Catalysts for Skin Ageing," Int J Mol Sci, 2021
• Sferrazza et al., "The Reconstructed Skin Model as a New Tool for Investigating Dermal Fillers: Increased Fibroblast Activity by Hyaluronic Acid," BioMed Res Int, 2015
• Mondon et al., "Biological Effects Induced by Specific AGEs in the Reconstructed Skin Model of Ageing," BioMed Res Int, 2015