HA PDRN+ Serum: How to Incorporate It into Your Skincare Routine

If you've been hearing about PDRN in skincare, there's a good reason — this DNA-derived ingredient, long used in aesthetic medicine, is now available in topical formulations. L'Oréal Paris Revitalift Filler Hyaluronic PDRN+ Anti-Wrinkle Plumping Serum brings together PDRN+ and Hyaluronic Acid in one formula, making it easy to incorporate this new ingredient into your daily routine.

What Is PDRN and Why Is It in Skincare?

PDRN (Polydeoxyribonucleotide) is made from DNA fragments, traditionally salmon sperm, and has become highly sought after in aesthetic medicine and clinics, where it is renowned for its ability to help improve overall skin quality and radiance.

Until recently, PDRN was only available through injectable skin booster procedures popular in Korean aesthetic clinics. L'oréal Paris is championing this movement within topical skincare, launching an advanced serum innovation inspired by filler and skin booster procedures*.

L'Oréal Paris' exclusive PDRN+ — a complex of PDRN and PRN produced through bio-fermentation — is pure, vegan**, and 3000x smaller than a pore size, for optimal absorption into the skin’s surface. It is exclusive to L'Oréal Group.

*Revitalift Filler Hyaluronic PDRN+ Serum is a cosmetic skincare product for topical use. Results not equal to a procedure.
**Ingredient not of animal origin

Why Should You Add a PDRN Serum to Your Routine?

Most anti-ageing serums focus on surface-level improvements — hydrating, smoothing, or temporarily plumping the skin. PDRN works differently. Its mechanism of action targets the cellular level, supporting the skin's own capacity to regenerate. This means the benefits are not just cosmetic but structural, delivering instant and long-term skin transformation by addressing the deeper causes of aging rather than only its visible symptoms.

An anti-ageing serum can help with a number of visible improvements — hydrating, smoothing, and plumping the skin. PDRN is known for going beyond this, helping to support the skin's natural moisture barrier and promote a refreshed, revitalised and glowing appearance.

Our formula is enriched with both Hyaluronic Acid and PDRN+ and it has been designed to target visible signs of ageing, delivering an instant boost in hydration and a visibly transformed, glowing, plump and smoother complexion. It also targets the appearance of fine lines and wrinkles.

Here's how both Hyaluronic Acid and PDRN ingredients can complement each other:

How to Apply Your Revitalift Hyaluronic PDRN+ Serum

Getting the most out of a PDRN serum comes down to when and how you apply it. Here are a few key tips to maximise absorption and results:

• Apply to damp skin: After cleansing, leave skin slightly damp. This helps the serum's active ingredients absorb more effectively.
• Use a small amount: A few drops are enough for the full face and neck. The Revitalift Filler serum has a fluid, transparent and lightweight texture that absorbs quickly on the skin — an addictive sensory experience that's non-sticky and non-greasy.
• Press, don't rub: Gently press the serum into the skin with upward motions. Avoid pulling or dragging, especially around the delicate eye area.
• Use twice daily: Apply morning and evening for best results. Follow with a moisturiser, and an SPF as part of your morning routine.

Building Your Complete Routine with PDRN

A PDRN serum works best as part of a simple, consistent routine. Here's where it fits in your daily routine:

1. Cleanse: A gentle cleanser to remove impurities without stripping the skin barrier.
2. Serum — L'Oréal Paris Revitalift Filler Hyaluronic PDRN+ Anti-Wrinkle Plumping Serum: Apply on damp skin, morning and evening.
3. Moisturise: Layer a moisturiser suited to your skin type to seal in the serum.
4. SPF (AM): Finish with broad-spectrum sunscreen every morning — essential to protect skin from UV-induced aging and preserve the benefits of your routine.

"PDRN marks the transition from protection to bio-stimulation. Acting as a true 'skin Red Bull,' it restores glow and elasticity. Paired with HA, it forms the ultimate 'Power Couple': HA provides immediate comfort at the surface, PDRN ensures long-lasting transformation." — Dr. Marie-Céline Frantz*, Small Molecule Bioactives & Nucleic Acids Expert, L'Oréal R&I #GlowBoost

"Our new Revitalift Filler Hyaluron PDRN + Anti-Wrinkle Plumping Serum relies on the addition of PDRN+ to the existing hyaluronic acid-based formula. This combination supports the serum's established short- and long-term plumping performance and contributes to the visible improvement of lines and wrinkles over time. The addition of PDRN further supports visible benefits on skin glow, elasticity and texture. Evaluated on all skin tones, the formula delivers skin transformation performance on visible signs of skin aging." — Charlotte Boissard, Skincare Scientific Valorization, L'Oréal Paris

Proven Results

Incorporate the #1 Serum in the World, now with PDRN+, into your routine for visible results. Here's what clinical testing has shown:

Average results – ¹Clinical study with 58 women after 8 weeks, twice daily use. ²Clinical study with 53 women after 6 weeks, twice daily use. Expert visual grading. Individual results will vary.

Tested for all skin types and tones, including sensitive skin.

*Important Note: Claims from Dr. Frantz are based exclusively on published scientific literature:

• Squadrito et al., "Pharmacological Activity and Clinical Use of PDRN," Frontiers in Pharmacology, 2017
• Kim et al., "Polynucleotide and Hyaluronic Acid Mixture for Skin Wound Healing," Tissue Eng Regen Med, 2025
• Akaberi et al., "PDRN in Skincare and Cosmetics: Mechanisms and Applications," J Skin Stem Cell, 2025

Sources:

• Squadrito et al., "Pharmacological Activity and Clinical Use of PDRN," Frontiers in Pharmacology, 2017
• Brun et al., "Fibroblasts from the Human Skin Dermo-Hypodermal Junction," Cells, 2020
• Diaz et al., "Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging," Dermatol Ther (Heidelb), 2021